Sonic Hedgehog Antikörper

Produktnummer ABIN6147930

Der Kaninchen Monoklonal Anti-Sonic Hedgehog-Antikörper wurde für WB und IF validiert. Er ist geeignet, Sonic Hedgehog in Proben von Human zu detektieren.

Kurzübersicht für Sonic Hedgehog Antikörper (ABIN6147930)

Target: Sonic Hedgehog (SHH)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Sonic Hedgehog Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Sonic Hedgehog Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human Sonic Hedgehog (Shh) (Shh)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000, IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Sonic Hedgehog

Target: Sonic Hedgehog (SHH)

Andere Bezeichnung: SHH

Hintergrund: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.,HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS,Angiogenesis,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Embryonic Stem Cells,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,Hedgehog Signaling Pathway,Neural Stem Cells,Stem Cells,Tumor suppressors,SHH

Molekulargewicht: 51 kDa

Gen-ID: 6469

UniProt: Q15465

Pathways: Hedgehog Signalweg, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development